Polynucleotides repair and rejuvenate the skin, improving hydration, elasticity and overall skin quality for natural, long lasting radiance.
Polynucleotides Treatment Summary
Our patients return to us year after year for natural, balanced results. Every review reflects our commitment to precision, safety and a personalised approach to aesthetic care.
PhilArt is one of the latest, cutting edge skin injectable treatment which improves skin quality and texture. NOT a dermal filler but comprised of polynucleotides which are chains of nucleotides that are essentially the building blocks which make up DNA. When Polynucleotides are introduced into the skin through multiple small injections, they help damaged DNA cells to repair and stimulate fibroblast cells, which help form connective tissues like collagen and elastin – the essential proteins that provide the skin with shape, volume and a youthful, radiant appearance.
PhilArt Polynucleotides are suitable for all skin types and can treat the face, neck, product range means the ingredients can tailored for all skin types and ages groups to the desired treatment areas which include the face, scalp and neck, décolletage, hands. and the delicate eye area.
PhilArt Eye is a dedicated injection treatment for the delicate area around the eyes to revive tired-looking eyes, for young and mature patients.
Based on natural ingredients The polynucleotides (PN) are of natural origin and derived from European freshwater fish intended for human consumption, with full control over the production chain.
The manufacturing process is based on the polynucleotide high purification technology (PN-HPT®), leading to a superior level of purification, thus ensuring product safety. Proven safety and efficacy Polynucleotides have a proven safety and efficacy profile with high tolerability and low risk of adverse events4, supported by extensive clinical data. Their use is based on more than 70 years of research and more than 100 published studies presented at national and international congresses.
Polynucleotides offer natural-looking results with minimal risk. They enhance skin texture, address skin discoloration, and subtly increase volume and tightness, particularly under the eyes. With collagen-boosting properties and enhanced hydration, they act as a potent injectable moisture treatment. Suitable for both preventative care in younger skin and rejuvenation in aging skin, polynucleotides serve as versatile solutions for skin health and vitality.
You will be invited for a medical consultation to assess your suitability for Polynucleotide treatment.
Polynucleotides are ideal for improving:
Fine lines and early ageing
Loss of elasticity
Dull, tired or dehydrated skin
Dark under-eye circles
Acne-prone or stressed skin
Redness and inflammation
Crepey texture
They can be used on the face, neck, chest and delicate areas such as the under-eyes.
Most patients require a course of 2–4 treatments, spaced 2–4 weeks apart. Maintenance sessions every 6–9 months help sustain long-term results.
Some early improvements such as hydration and radiance may be seen within days, but the deeper regenerative effects build gradually over 4–8 weeks as collagen and elastin increase.
Yes. Polynucleotides are one of the most effective treatments for the delicate under-eye area, helping to brighten dark circles, improve elasticity and smooth crepey skin without adding volume.
Most patients find the treatment very comfortable. A topical numbing cream can be applied beforehand, and the injections are quick and precise.
Downtime is minimal. Mild redness, swelling or tiny bumps at the injection points may appear but typically settle within a few hours to 24 hours.
Unlike fillers, polynucleotides do not add volume or change facial structure.
Unlike Profhilo, which focuses on hydration and elasticity, polynucleotides stimulate deeper tissue repair, reduce inflammation and support long-term cellular regeneration.
Yes. They work particularly well alongside:
Microneedling
Exosomes
Mesotherapy
Profhilo
Dermal fillers (staggered appropriately)
Energy-based treatments
Dr Joney will advise the best combination for your goals.
Yes. Polynucleotide products such as PhilArt are rigorously tested, highly purified and biocompatible. They integrate naturally with the skin’s repair processes.
No. Polynucleotides improve skin quality, not shape. You will look fresher, smoother and more revitalised, but still completely natural.
Every polynucleotide treatment at Dr Joney De Souza Clinic begins with a detailed, personalised consultation. During this appointment, Dr Joney will take time to understand your concerns, assess your skin quality and areas of early ageing, and discuss the improvements you’d like to achieve. He will explain how polynucleotides work, the regenerative benefits you can expect, and whether combining the treatment with other skin rejuvenation techniques may enhance your overall results.
Once your bespoke plan is agreed, the skin is gently cleansed and a topical anaesthetic may be applied to ensure comfort. Using precise micro-injection techniques, Dr Joney administers small amounts of polynucleotide formula into targeted areas. The treatment is quick and designed to stimulate skin repair, improve hydration and support collagen and elastin production for healthier, more resilient skin. Discomfort is minimal and there is no significant downtime.
After your polynucleotide treatment, you can return to your normal activities straight away. You may notice slight redness, swelling or small bumps at the injection points, which usually settle within a few hours to 24 hours as the product begins to integrate with the skin.
Dr Joney will provide personalised aftercare advice, which may include avoiding strenuous exercise, heat treatments and applying pressure to the treated areas for 24 to 48 hours. As the regenerative processes are activated, the skin gradually becomes smoother, brighter and more hydrated over the following weeks. Most patients complete a recommended course of treatments for optimal results.
With regular maintenance sessions, you’ll notice long-lasting improvements in texture, elasticity and overall skin quality, creating a naturally refreshed appearance that still looks completely like you.
All products used are UK-sourced, premium quality and FDA approved. With a focus on excellence, service, and safety, every treatment is tailored to you. If you have any questions around our pricing please give us a call.
All treatments consist of 1 session unless it is a package, which will have multiple sessions based on treatment.
All Pricing is in GBP.
| Area/Treatment | Price with Dr Joney | Price with Associate |
|---|---|---|
Polynucleotides - 1 area | 480 | 410 |
Polynucleotides - 2 areas | 800 | 680 |
Polynucleotides - 3 areas | 950 | 810 |
Polynucleotides - Mouth area (‘smoker’s lines’) & Lower face | 325 | 275 |
Based at 49 Blandford Street in Marylebone, Dr Joney De Souza Skin & Laser Clinic is known for its refined, personalised approach to aesthetic medicine. Under the expert care of Dr Joney, every treatment is tailored to enhance natural beauty and maintain long-term skin health.
Dr Joney will advise you on aftercare, such as avoiding strenuous exercise or massaging the area for 24 hours. Many patients choose to book a review appointment around two weeks later, where any fine-tuning can be carried out if necessary.
Results typically last between three to six months, depending on your individual response and the area treated. With regular maintenance treatments, you’ll notice smoother skin, softer lines, and a fresher, more relaxed appearance that still looks entirely natural.
Our team would love to hear from you. Whether you have questions, need guidance, or simply want to explore your treatment options, we’re here to support you every step of the way. Reach out in whichever way feels easiest
